Kalymnos is the "proud mother" of great Kalymnian painters and sculptors, such as:
S. Maglis, G. Oikonomou, E. Zairis, M. Alachouzos, S. Galouzis, A. Karafyllakis, T. Kourounis, T. Billiris, I. Tatari, and many others.

Particularly impressive is the Holy Church of the Savior Christ in the Cathedral of Kalymnos, where there are works by almost all the great artists of the island, inspired by the Renaissance.

The museums of Kalymnos present exceptional interest:

• Archaeological Museum of Kalymnos: A gem of aesthetic and historical value with unique findings.
• Vouvális Mansion: Showcases the urban life of old Kalymnos.
• Naval & Folklore Museum: Dedicated to the tradition of sponge diving and seafaring.
• Museum of Marine Life and Finds of Valsamidis: A private collection of unique value.
• “Neoclassical” of Kyrannis and the Traditional Kalymnian House: Keep the local cultural identity alive.

Kalymnos hosts numerous buildings and monuments rich in decoration and intricate architectural style. Among them, notable religious monuments include:

• The Holy Church of Saint Nicholas
• The Holy Monastery of Saint Savvas

The island boasts impressive castles of strategic and historical significance, such as:

• The Great Castle, also known as the Castle of Chora
• The Castle of Chrysocheria
• The Kastelli

Kalymnos is filled with stunning churches and monasteries, built over the centuries, featuring works by local artists and magnificent marble iconostases.

Notable among them are:

• The Holy Monastery of Saint Panteleimon
• The Cathedral of Saint Savvas the Miracle Worker, which attracts many visitors every year.